There are five main intrinsic or molecular subtypes of breast cancer that are based on the genes a cancer expresses: Luminal A breast cancer is hormone-receptor positive (estrogen-receptor and/or progesterone-receptor positive), HER2 negative, and has low levels of the protein Ki-67, which helps control how fast cancer cells grow.
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Effect of Ki‐67 on Immunohistochemical Classification of Luminal A to Luminal B Subtypes of Breast Carcinoma. Ki-67 has been used as an adjunct in separating tumors into these two categories, though MCM2 appears to … Magno Belém Cirqueira BSc, MSc. Indeed, 400 (58.9%) patients in the subcohort were classified as having “Luminal A-like” and 279 (41.1%) “Luminal B … In an independent cohort of 4046 patients with breast cancer, 2847 had hormone receptor-positive tumors. BCs expressing high levels of Ki67, a nuclear marker of cell proliferation, are associated with worse outcome [8] , [9] , [10] .
Luminal A subtype was defined as being ER positive, HER2 negative, and Ki67 low (<14% cells positive) and luminal B subtype as being ER positive, HER2 negative, and Ki67 high (≥ 14% cells positive).
Luminal tumors were also subgrouped into risk categories based on the PR and TP53 status. Luminal A versus luminal B breast cancer: MammaTyper mRNA versus immunohistochemical subtyping with an emphasis on standardised Ki67 labelling‐based or mitotic … The major biological distinction between Luminal A and B is the proliferation signature, which has higher expression in Luminal B tumors than in Luminal A tumors , . Biomedical of Pathology Department, Teaching Hospital, Federal University of Goiás, Goiânia, Goiás, Brazil. In addition, global Ki67-based surrogate subtypes reached higher concordance with PAM50 molecular subtype for luminal A and B tumors (66.3% concordance rate, κ = 0.345), than using hot spot scoring (55.8% concordance rate, κ = 0.250). Luminal A vs. Luminal B Among breast cancers that are hormone-positive, there are two distinct subtypes that have different prognoses and respond differently to treatment.
The best Ki67 index cut point to distinguish luminal B from luminal A tumors was 13.25%. Ki-67 evaluation in this cohort enabled maximizing the number of patients classified as having ‘Luminal A-like’ intrinsic subtype for whom the use of cytotoxic drugs could be at large avoided. Survival analysis was performed.
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